Antioxidant Lignans from the Fruits of Broussonetia papyrifera

被引：72
|
作者：
Mei, Ren-Qiang [1 ,2 ]
Wang, Yue-Hu [1 ]
Du, Guan-Hua [3 ]
Liu, Guang-Ming [4 ]
Zhang, Li [1 ,3 ]
Cheng, Yong-Xian [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[4] Dali Univ, Coll Pharmaceut Sci, Dali 671002, Yunnan, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 04期
关键词：
HYDROGEN-PEROXIDE; CONSTITUENTS; INHIBITORS; LEAVES; NEOLIGNAN;
D O I：
10.1021/np800488p
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Nine new lignans, chushizisins A-I (1-9), and three known lignans, threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (10), erythro-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (11), and 3-[2-(4- hydroxyphenyl)-3-hydroxymethyl-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol (12), were isolated from the fruits of Broussonetia papyrifera. Their structures were elucidated using spectroscopic methods. Compounds 1, 5, 6, 8, 9, and 11 exhibited antioxidant activities against H2O2-induced impairment in PC12 cells, while compounds 1, 2, 4, 7, and 11 showed DPPH radical-scavenging activities with IC50 values of 236.8, 156.3, 273.9, 281.1, and 60.9 mu M, respectively.
引用
收藏
页码：621 / 625
页数：5
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