How does a polymer brush repel proteins?

被引:20
|
作者
Wu, Chi [1 ,2 ]
机构
[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
[2] Univ Sci & Technol China, Dept Chem Phys, Open Lab Bond Select Chem, Hefei 230026, Peoples R China
基金
中国国家自然科学基金;
关键词
Polymer brush; Protein adsorption; Antifouling; POLY(ETHYLENE GLYCOL); CHAIN DENSITY; ADSORPTION; RESISTANCE; SURFACES;
D O I
10.1007/s10118-014-1539-1
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The captioned question has been addressed by the steric effect; namely, the adsorption of proteins on a surface grafted with linear polymer chains decreases monotonically as the grafting density increases. However, there is no quantitative and satisfactory explanation why the adsorption starts to increase when the grafting density is sufficiently high and why polyethylene glycol (PEG) still remains as one of the best polymers to repel proteins. After considering each grafted chain as a molecular spring confined inside a "tube" made of its surrounding grafted chains, we estimated how its free energy depends on the grafting density and chain length, and calculated its thermal energy-agitated chain conformation fluctuation, enabling us to predict an adsorption minimum at a proper grafting density, which agrees well with previous experimental results. We propose that it is such a chain fluctuation that slows down the adsorption kinetically.
引用
收藏
页码:1575 / 1580
页数:6
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