Induction of gene encoding FABP4 in Pten-null keratinocytes

被引：17
|
作者：
Tsuda, Masaaki [1 ]
Inoue-Narita, Tae [1 ]
Suzuki, Akira [2 ]
Itami, Satoshi [3 ]
Blumenberg, Miroslav [4 ]
Manabe, Motomu [1 ]
机构：
[1] Akita Univ, Sch Med, Dept Dermatol & Plast Surg, Akita 0108543, Japan
[2] Kyushu Univ, Med Inst Bioregulat, Div Embryon & Genet Engn, Fukuoka 812, Japan
[3] Osaka Univ, Grad Sch Med, Dept Regenerat Dermatol, Osaka, Japan
[4] NYU, Sch Med, Dept Dermatol, New York, NY USA
来源：
FEBS LETTERS | 2009年 / 583卷 / 08期
关键词：
Pten; FABP4; PPAR gamma; Sebaceous gland; Microarray; ACID-BINDING PROTEIN; EPIDERMAL-KERATINOCYTES; SEBACEOUS GLAND; BETA-CATENIN; SKIN; DIFFERENTIATION; EXPRESSION; ROLES; GAMMA; CELL;
D O I：
10.1016/j.febslet.2009.03.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1319 / 1322
页数：4
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