Akt1/Akt2 and mTOR/Bim play critical roles in osteoclast differentiation and cEll survival, respectively, while akt is dispensable for cell survival in isolated osteoclast precursors

被引:0
|
作者
Sugatani, T [1 ]
Hruska, KA [1 ]
机构
[1] Washington Univ, St Louis, MO USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S51 / S51
页数:1
相关论文
共 50 条
  • [21] AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
    Riggio, Marina
    Perrone, Maria C.
    Polo, Maria L.
    Rodriguez, Maria J.
    May, Maria
    Abba, Martin
    Lanari, Claudia
    Novaro, Virginia
    SCIENTIFIC REPORTS, 2017, 7
  • [22] Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
    Zhao, Zhijian
    Robinson, Ronald G.
    Barnett, Stanley F.
    Defeo-Jones, Deborah
    Jones, Raymond E.
    Hartman, George D.
    Huber, Hans E.
    Duggan, Mark E.
    Lindsley, Craig W.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (01) : 49 - 53
  • [23] Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population
    Zhu, Jinhong
    Wang, Mengyun
    He, Jing
    Zhu, Meiling
    Wang, Jiu-Cun
    Jin, Li
    Wang, Xiao-Feng
    Yang, Ya-Jun
    Xiang, Jia-Qing
    Wei, Qingyi
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 (04) : 666 - 677
  • [24] Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells
    Sahlberg, Sara Haggblad
    Mortensen, Anja C.
    Haglof, Jakob
    Engskog, Mikael K. R.
    Arvidsson, Torbjorn
    Pettersson, Curt
    Glimelius, Bengt
    Stenerlow, Bo
    Nestor, Marika
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 50 (01) : 5 - 14
  • [25] Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells
    Mahmoud Toulany
    Julia Maier
    Mari Iida
    Simone Rebholz
    Marina Holler
    Astrid Grottke
    Manfred Jüker
    Deric L Wheeler
    Ulrich Rothbauer
    H Peter Rodemann
    Cell Death Discovery, 3
  • [26] Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells
    Toulany, Mahmoud
    Maier, Julia
    Lida, Mad
    Rebholz, Simone
    Holler, Marina
    Grottke, Astrid
    Jueker, Manfred
    Wheelers, Deric L.
    Rothbauer, Ulrich
    Rodemann, H. Peter
    CELL DEATH DISCOVERY, 2017, 3
  • [27] Role of Akt2 in cell survival and metastasis of colorectal cancer (CRC) cells
    Agarwal, Ekta
    CANCER RESEARCH, 2015, 75
  • [28] Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis
    Cui, Yu
    Chen, Xufeng
    Zhang, Jiali
    Sun, Xiang
    Liu, Haifeng
    Bai, Li
    Xu, Chenqi
    Liu, Xiaolong
    CELL REPORTS, 2016, 15 (02): : 256 - 263
  • [29] Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells
    Shearn, Colin T.
    Reigan, Philip
    Petersen, Dennis R.
    FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 (01) : 1 - 11
  • [30] Influence of AKT1, AKT2 and FRAP1 polymorphisms on response and survival in head and neck cancer (SCCHN) patients treated with Docetaxel and Cetuximab
    Pfisterer, K.
    Fusi, A.
    Klinghammer, K.
    Knoedler, M.
    Nonnenmacher, A.
    Keilholz, U.
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2010, 15 : 90 - 91