SELECTIVE ACTIVATION OF NUCLEAR FACTOR KAPPA B IN THE COCHLEA BY SENSORY AND INFLAMMATORY STRESS

被引:40
|
作者
Adams, J. C. [1 ]
Seed, B. [2 ]
Lu, N. [2 ]
Landry, A. [2 ]
Xavier, R. J. [2 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA
基金
美国国家卫生研究院;
关键词
SPIRAL LIGAMENT FIBROCYTES; SENSORINEURAL HEARING-LOSS; INNER-EAR; DOWN-REGULATION; EXPRESSION; RECEPTOR; DEAFNESS; CYTOKINES; PROTEIN; DAMAGE;
D O I
10.1016/j.neuroscience.2009.02.073
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Damage response pathways triggered by mechanical stress might reasonably be expected to be conserved throughout evolution. However, using a nuclear factor kappa B (NF-kappa B) reporter mouse we show here that this phylogenetically recent transcription factor plays a major role in the response to mechanosensory stress in the mammalian inner ear. The protective action of NF-kappa B is exerted in neither sensory nor non-sensory epithelial cells, but rather in connective tissue cells within the spiral ligament and spiral limbus. In the spiral ligament, predominantly type I fibrocytes are activated following noise exposure, whereas type II fibrocytes are activated following systemic inflammatory stress. Immune-mediated and acoustic trauma-mediated hearing loss syndromes in humans may in part result from the vulnerability of type II and type I fibrocytes to systemic inflammatory stress and acoustic trauma, respectively. Unexpected cell-specific and stress-specific NF-kappa B activation found in the inner ear in this in vivo study suggest that this approach may have wide applications in demonstrating similar specializations of stress responses in other tissues, including the brain. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:530 / 539
页数:10
相关论文
共 50 条
  • [21] Effects of septic plasma on nuclear factor kappa B (NFkB) activation in astrocytes: Role of oxidant stress and NO
    Handa, O
    Rui, T
    Kvietys, PR
    Wilson, JX
    Cepinskas, G
    FASEB JOURNAL, 2004, 18 (04): : A444 - A444
  • [22] Nuclear factor kappa B activation is required for endotoxin-induced
    B. J. Manning
    J. H. Wang
    Q. D. Wu
    H. P. Redmond
    Irish Journal of Medical Science, 2002, 171 (Suppl 2)
  • [23] Butyrate-mediated inhibition of nuclear factor kappa b activation
    Luhrs, H
    Schauber, J
    Boxberger, F
    Dusel, G
    Krott, K
    Kelber, E
    Menzel, T
    Scheppach, W
    GASTROENTEROLOGY, 1999, 116 (04) : A563 - A563
  • [24] Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis
    Meng, Yong
    Ma, Qing-Yong
    Kou, Xiao-Ping
    Xu, Jun
    WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (04) : 525 - 528
  • [25] Activation Of The Glutaredoxin-1 Gene By Nuclear Factor Kappa B:Feed Forward Amplification Of Inflammatory Responses
    Aesif, S. W.
    Anathy, V.
    van der Velden, J. L.
    Guala, A. S.
    Reiss, J. N.
    Ho, Y.
    Janssen-Heininger, Y. M. W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
  • [27] Activation of nuclear factor κB in inflammatory bowel disease
    Schreiber, S
    Nikolaus, S
    Hampe, J
    GUT, 1998, 42 (04) : 477 - 484
  • [28] Selective inhibition of BET bromodomain and their effect on nuclear factor-kappa B activation in pulmonary arterial hypertension
    Gambaryan, Natalia
    Meng, Chao
    Perros, Frederic
    Guignabert, Christophe
    Tu, Ly
    Humbert, Marc
    Adcock, Ian
    Wort, Stephen
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [29] Nuclear factor-kappa B and its role in inflammatory lung disease
    Alharbi, Khalid Saad
    Fuloria, Neeraj Kumar
    Fuloria, Shivkanya
    Rahman, Sk Batin
    Al-Malki, Waleed Hassan
    Shaikh, Mohammad Arshad Javed
    Thangavelu, Lakshmi
    Singh, Sachin K.
    Allam, Venkata Sita Rama Raju
    Jha, Niraj Kumar
    Chellappan, Dinesh Kumar
    Dua, Kamal
    Gupta, Gaurav
    CHEMICO-BIOLOGICAL INTERACTIONS, 2021, 345
  • [30] Nuclear factor kappa B is a promising therapeutic target in inflammatory lung disease
    Park, Gye Young
    Christman, John W.
    CURRENT DRUG TARGETS, 2006, 7 (06) : 661 - 668