Protein tyrosine phosphatases: from genes, to function, to disease

被引：1263
|
作者：
Tonks, Nicholas K. [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2039
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
引用
收藏
页码：833 / 846
页数：14
相关论文
共 50 条
  • [31] The structure and function of protein tyrosine phosphatases and their role in insulin signaling.
    Visnick, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 314 - MEDI
  • [32] Protein tyrosine phosphatases: Structure and function, substrate specificity, and inhibitor development
    Zhang, ZY
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2002, 42 : 209 - 234
  • [33] Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases
    Li, LW
    Dixon, JE
    SEMINARS IN IMMUNOLOGY, 2000, 12 (01) : 75 - 84
  • [34] GnRH gene products downregulate their neighboring genes encoding protein tyrosine phosphatases
    K. Okubo
    K. Aida
    Fish Physiology and Biochemistry, 2003, 28 : 23 - 24
  • [35] GnRH gene products downregulate their neighboring genes encoding protein tyrosine phosphatases
    Okubo, K
    Aida, K
    FISH PHYSIOLOGY AND BIOCHEMISTRY, 2003, 28 (1-4) : 23 - 24
  • [36] Perturbing Protein and Ligand Conformational Landscapes to Link Dynamics and Function in Protein Tyrosine Phosphatases
    Mehlman, Tamar
    Margent, Liliana
    Ebrahim, Ali
    Woods, Virgil
    Singh, Nathanael
    Riley, Blake
    Azeem, Syeda Maryam
    Hossain, Sakib
    Keedy, Daniel
    PROTEIN SCIENCE, 2023, 32 (12)
  • [37] The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer?s disease
    Zhao, Xia
    Xiong, Li
    She, Lingyu
    Li, Liwei
    Huang, Ping
    Liang, Guang
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 151
  • [38] Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis
    Ruddraraju, Kasi Viswanatharaju
    Aggarwal, Devesh
    Zhang, Zhong-Yin
    MICROORGANISMS, 2021, 9 (01) : 1 - 13
  • [39] Bidentate Inhibitors of Protein Tyrosine Phosphatases
    Low, Joo-Leng
    Chai, Christina L. L.
    Yao, Shao Q.
    ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (14) : 2225 - 2250
  • [40] HEPATIC PROTEIN TYROSINE PHOSPHATASES IN THE RAT
    GRUPPUSO, PA
    BOYLAN, JM
    SMILEY, BL
    FALLON, RJ
    BRAUTIGAN, DL
    BIOCHEMICAL JOURNAL, 1991, 274 : 361 - 367
12345