Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles

被引：33

作者：

Kanchupalli, Vinaykumar ^{[1
]}

Joseph, Desna ^{[1
]}

Katukojvala, Sreenivas ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem, Bhopal 462066, Madhya Pradesh, India

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 23期

关键词：

ENALCARBENOIDS DIRECT SYNTHESIS; TERMINAL ALKYNES; DENITROGENATIVE ANNULATION; MULTICOMPONENT REACTIONS; SATURATED HETEROCYCLES; EFFICIENT SYNTHESIS; AZAVINYL CARBENES; FACILE SYNTHESIS; INDOLES; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.5b03064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.

引用

页码：5878 / 5881

页数：4

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