The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for patients with Bone Metastases: The EORTC QLQ-BM22

被引：96

作者：

Chow, Edward ^{[1
]}

Hird, Amanda ^{[1
]}

Velikova, Galina ^{[2
]}

Johnson, Colin ^{[3
]}

Dewolf, Linda ^{[4
]}

Bezjak, Andrea ^{[5
]}

Wu, Jackson ^{[6
]}

Shafiq, Jesmin ^{[7
]}

Sezer, Orhan ^{[8
]}

Kardamakis, Dimitrios ^{[9
]}

van der Linden, Yvette ^{[10
]}

Ma, Brigette ^{[11
]}

Castro, Monica ^{[12
]}

Foro Arnalot, Palmira ^{[13
]}

Ahmedzai, Sam ^{[14
]}

Clemons, Mark ^{[5
]}

Hoskin, Peter ^{[15
]}

Yee, Albert ^{[1
]}

Brundaye, Michael ^{[16
]}

Bottomley, Andrew ^{[4
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Univ Leeds, St James Univ Hosp, Canc Res UK Clin Ctr, Leeds, W Yorkshire, England

[3] Southampton Gen Hosp, Univ Surg Unit, Southampton, Hants, England

[4] European Org Res Treatment Canc, Brussels, Belgium

[5] Univ Toronto, Princess Margaret Hosp, Univ Hlth Network, Toronto, ON, Canada

[6] Univ Calgary, Tom Baker Canc Ctr, Calgary, AB, Canada

[7] Liverpool Hosp, Liverpool, NSW, Australia

[8] Univ Med Berlin, Charite, Berlin, Germany

[9] Univ Patras, Sch Med, GR-26110 Patras, Greece

[10] Radiotherapeut Inst Friesland, Leeuwarden, Netherlands

[11] Chinese Univ Hong Kong, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[12] Univ Buenos Aires, Inst Oncol Angel H Roffo, RA-1053 Buenos Aires, DF, Argentina

[13] Hosp Esperanza, Barcelona, Spain

[14] St Lukes Hosp, Sheffield, S Yorkshire, England

[15] Mt Vernon Hosp, Northwood HA6 2RN, Middx, England

[16] Kingston Reg Canc Ctr, Kingston, ON, Canada

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 07期

关键词：

Bone metastases; Health-related quality of life; Questionnaire; Cancer; Pain symptoms; EORTC; SUPPORTIVE PAMIDRONATE TREATMENT; BREAST-CANCER; PROSTATE-CANCER; CONTROLLED-TRIAL; ZOLEDRONIC ACID; ORAL CLODRONATE; PAIN; IBANDRONATE; PLACEBO; CARCINOMA;

D O I：

10.1016/j.ejca.2008.11.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: The aim of this study was to develop a bone metastases module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) or the EORTC QLQ-C15-PAL for patients with bone metastases. Methods Phases 1-2 of module development were conducted in Canada, Australia and Germany according to EORTC QOL group guidelines. Phase 3 was conducted in nine countries in seven languages. Results: Sixty-one health-related quality of life (HRQOL) issues were generated from health care professionals (n = 152) and patients (n = 413). This resulted in a 22-item provisional module. Further testing in 170 patients from nine countries resulted in the EORTC QLQ-BM22 module, containing 22 items, conceptualised into both symptom scales, with five painful sites and three pain characteristics, and also functional scales, with eight functional interference and six psychosocial aspects. Conclusion: This study provides a provisional comprehensive HRQOL measurement tool for future trials, which will continue to undergo further validation. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1146 / 1152

页数：7

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