Cancer Risk and Surveillance in Primary Sclerosing Cholangitis

被引：41

作者：

Folseraas, Trine ^{[1
,2
,3
]}

Boberg, Kirsten Muri ^{[1
,2
,3
]}

机构：

[1] Oslo Univ Hosp, Rikshosp, Div Canc Med Surg & Transplantat, Dept Transplantat Med,Gastroenterol Sect, N-0424 Oslo, Norway

[2] Oslo Univ Hosp, Rikshosp, Div Canc Med Surg & Transplantat, Norwegian PSC Res Ctr,Dept Transplantat Med, N-0424 Oslo, Norway

[3] Univ Oslo, Rikshosp, Inst Clin Med, N-0027 Oslo, Norway

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 01期

关键词：

Primary sclerosing cholangitis; Carcinoma; Dysplasia; Cholangiocarcinoma; Inflammatory bowel disease; Surveillance; Brush cytology; INFLAMMATORY-BOWEL-DISEASE; IN-SITU HYBRIDIZATION; DOSE URSODEOXYCHOLIC ACID; POPULATION-BASED COHORT; ULCERATIVE-COLITIS; LIVER-TRANSPLANTATION; COLORECTAL-CANCER; NATURAL-HISTORY; BRUSH CYTOLOGY; CLINICAL PRESENTATION;

D O I：

10.1016/j.cld.2015.08.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary sclerosing cholangitis (psq is a chronic, progressive disease characterized by inflammatory and fibrosing strictures of the biliary tree. PSC is associated with a high lifetime risk of hepatobiliary and colorectal cancers. The nature of the carcinogenic process in PSC is not well established. The lack of diagnostic methods for early detection and the limited therapeutic options for cholangiocarcinoma constitute a major challenge in the current handling of PSC patients. The article reviews the risk for cancer development in PSC and discusses surveillance strategies for PSC-associated cancers.

引用

页码：79 / +

页数：21

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