Plasma viscosity, fibrinogen and the metabolic syndrome: effect of obesity and cardiorespiratory fitness

被引:25
|
作者
Carroll, S [1 ]
Cooke, CB [1 ]
Butterly, RJ [1 ]
机构
[1] Leeds Metropolitan Univ, Sch Leisure & Sports Studies, Leeds LS6 3QS, W Yorkshire, England
关键词
insulin resistance; predicted V-O2max; haemorheology;
D O I
10.1097/00001721-200011010-00008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The association between both plasma viscosity and fibrinogen concentration with clustering of metabolic risk markers was examined within a cross-sectional study of employed middle-aged men. Analyses were performed on a subsample of 629 nonsmokers (46.7 +/- 7.8 years) without diabetes. The effect of obesity and cardiorespiratory fitness on these haemorheological parameters and their association with the metabolic syndrome was also investigated. The cohort was grouped by the number of metabolic markers present. Metabolic markers included high-density lipoprotein-cholesterol (< 1.13 mmol/l), triglycerides (greater than or equal to 1.805 mmol/l), glucose (greater than or equal to 5.5 mmol/l) and diastolic blood pressure (greater than or equal to 90 mmHg). The age-adjusted odds ratio for hyperviscosity (greater than or equal to 1.67 mPa/s) was 2.08 [95% confidence interval (CI), 1.06-4.05; P = 0.031] for the subjects with the metabolic syndrome (three or more metabolic markers) when compared with those with no metabolic abnormalities. The comparable age-adjusted odds ratio for hyperfibrinogenaemia (greater than or equal to 3.47 g/l) was non-significantly higher at 1.69 (95% CI, 0.87-3.27; P = 0.119). The mean age-adjusted plasma viscosity level and the prevalence of hyperviscosity increased significantly from 1.629 to 1.692 mPa/s (P = 0.0005) and from 21.0 to 36.0% with accumulating metabolic markers (P = 0.006). Plasma viscosity and fibrinogen concentration both increased with higher quartiles of skinfolds (P = 0.003 and P = 0.01, respectively) following adjustment for age, lipids and leucocyte count. Plasma viscosity was also significantly lower with higher levels of predicted maximum oxygen consumption (Vo(2max)) (P = 0.0005). The odds ratio for hyperviscosity in subjects with the metabolic syndrome as compared with those with no metabolic markers was attenuated following adjustment for age, sum of skinfolds and predicted maximum oxygen consumption (Vo(2max)) (1.44; 95% CI, 0.72-2.90; P = 0.307). These cross-sectional results suggest that plasma viscosity is associated with increased clustering of metabolic markers in middle-aged men of high socio-economic status. Obesity and poor cardiorespiratory fitness may be important in the development of haemorheological abnormalities associated with the metabolic syndrome. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:71 / 78
页数:8
相关论文
共 50 条
  • [31] Cardiorespiratory Fitness and Metabolic Risk
    Grundy, Scott M.
    Barlow, Carolyn E.
    Farrell, Stephen W.
    Vega, Gloria L.
    Haskell, William L.
    AMERICAN JOURNAL OF CARDIOLOGY, 2012, 109 (07): : 988 - 993
  • [32] Plasma viscosity in patients with metabolic syndrome
    Ucak, Sema
    Basat, Okcan
    Cetinkaya, Emel
    CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2013, 54 (01) : 15 - 22
  • [33] Plasma and blood viscosity in metabolic syndrome
    Irace, C.
    Scavelli, F.
    Carallo, C.
    Serra, R.
    Gnasso, A.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2009, 19 (07) : 476 - 480
  • [34] Relationship between cardiorespiratory fitness, metabolic syndrome and visceral obesity in overweight and obese pre-menopausal women
    Barata, JLT
    Rocha, P
    Carnero, E
    Cardoso, C
    Santa-Clara, H
    Teixeira, PJ
    Sardinha, LB
    INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 : S172 - S172
  • [35] Independent and Joint Associations of Cardiorespiratory Fitness and Muscle Fitness with Metabolic Syndrome in Korean Men
    Kim, Jongkyu
    Lee, Namju
    Jung, Seung Ho
    Kim, Eung-Joon
    Cho, Hyun-Chul
    METABOLIC SYNDROME AND RELATED DISORDERS, 2011, 9 (04) : 273 - 279
  • [36] Effect Modification of Cardiorespiratory Fitness, Obesity, and Physical Activity in Adults
    do Socorro Morais Pereira Simoes, Maria
    Wehrmeister, Fernando Cesar
    Romiti, Marcello
    de Toledo Gagliardi, Antonio Ricardo
    Arantes, Rodolfo Leite
    Dourado, Victor Zuniga
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2022, 43 (06) : 561 - 566
  • [37] The effect of cardiorespiratory fitness and obesity on cancer mortality in women and men
    Evenson, KR
    Stevens, J
    Cai, JW
    Thomas, R
    Thomas, O
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2003, 35 (02): : 270 - 277
  • [38] Cardiorespiratory Fitness, Obesity and Physical Activity in Schoolchildren: The Effect of Mediation
    Gonzalez-Galvez, Noelia
    Carlos Ribeiro, Jose
    Mota, Jorge
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 19 (23)
  • [39] Change In Cardiorespiratory Fitness And Prevalence Of Metabolic Syndrome After An Exercise Program
    Riccardi, Matthew
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2019, 51 (06): : 494 - 494
  • [40] Comparison Of Cardiorespiratory Fitness Between Adult Males With And Without Metabolic Syndrome
    Mileski, Kim S. L.
    Leitao, Joao Luiz A. E. P.
    Porto, Luiz Guilherme G.
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2012, 27 : 349 - 349