ANO1: an additional key player in cyst growth

被引：9
|
作者：
Tanaka, Tetsuhiro [1 ]
Nangaku, Masaomi [1 ]
机构：
[1] Univ Tokyo, Sch Med, Div Nephrol & Endocrinol, Tokyo 1138655, Japan
来源：
KIDNEY INTERNATIONAL | 2014年 / 85卷 / 05期
关键词：
POLYCYSTIC KIDNEY-DISEASE;
D O I：
10.1038/ki.2013.436
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an embryonic kidney cyst model. Their results support a potential role for this chloride channel in cyst generation.
引用
收藏
页码：1007 / 1009
页数：3
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