ANO1: an additional key player in cyst growth

被引：9

作者：

Tanaka, Tetsuhiro ^{[1
]}

Nangaku, Masaomi ^{[1
]}

机构：

[1] Univ Tokyo, Sch Med, Div Nephrol & Endocrinol, Tokyo 1138655, Japan

来源：

KIDNEY INTERNATIONAL | 2014年 / 85卷 / 05期

关键词：

POLYCYSTIC KIDNEY-DISEASE;

D O I：

10.1038/ki.2013.436

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an embryonic kidney cyst model. Their results support a potential role for this chloride channel in cyst generation.

引用

页码：1007 / 1009

页数：3

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