Zinc protection of mercury-induced hepatic toxicity in mice

被引:0
|
作者
Afonne, OJ [1 ]
Orisakwe, OE
Ndubuka, GI
Akumka, DD
Ilondu, N
机构
[1] Nnamdi Azikiwe Univ, Coll Hlth Sci, Dept Pharmacol, Nnewi, Anambra State, Nigeria
[2] Natl Inst Pharmaceut Res & Dev, Abuja, Nigeria
关键词
mercury; zinc; parenchyma; Kupfer cell;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The actions and interactions of heavy metals on certain organ functions have been of concern, since occupational exposure to certain metals results in impairment of functions. Studies were carried out to determine the effects of zinc (Zn) and mercury (Hg) on murine liver. CD-1 male mice were administered 4 ppm HgCl2, 800 ppm ZnCl2, 4 ppm HgCl2 + 800 ppm ZnCl2 or deionized water in their drinking water for 12 weeks. Histological evaluation of the liver confirmed the toxic effects of Hg, as well as the normal morphology of the Zn-exposed animals. A combined treatment of both metals resulted in protection of the Hg-induced liver damage by Zn, The results of this experiment indicate that Hg has a toxic effect on liver, while Zn has a protective action against such toxic effects.
引用
收藏
页码:305 / 308
页数:4
相关论文
共 50 条
  • [21] Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice
    Brenden, N
    Rabbani, H
    Abedi-Valugerdi, M
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 125 (02): : 202 - 210
  • [22] Exploring the potential of curry leaves on mercury-induced hepatorenal toxicity in an animal model
    Ijaz, Muhammad
    Arshad, Asma
    Awan, Muhammad Ahmad
    Tariq, Muhammad Rizwan
    Ali, Shinawar Waseem
    Ali, Sajid
    Shafiq, Muhammad
    Ahmed, Saeed
    Sheas, Muhammad Naveed
    Iftikhar, Madiha
    Ahmed, Sheraz
    Nasir, Muhammad Adnan
    Kausar, Ghazala
    Javed, Ammad ul Islam
    Safdar, Waseem
    FOOD SCIENCE & NUTRITION, 2022, 10 (02): : 499 - 506
  • [23] Glutamate-mediated effects of caffeine and interferon-γ on mercury-induced toxicity
    Engin, Ayse Basak
    Engin, Evren Doruk
    Golokhvast, Kirill
    Spandidos, Demetrios A.
    Tsatsakis, Aristides M.
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 39 (05) : 1215 - 1223
  • [24] TISSUE MERCURY LEVELS IN MERCURY-INDUCED NEPHROTIC SYNDROME
    BARR, RD
    SMITH, H
    CAMERON, HM
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1973, 59 (04) : 515 - 517
  • [25] Thiol compounds inhibit mercury-induced immunological and immunopathological alterations in susceptible mice
    Hu, H
    Moller, G
    AbediValugerdi, M
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1997, 107 (01): : 68 - 75
  • [26] The protective role of virgin olive oil and vitamin E on mercury-induced hepatic, renal, testicular and adrenal toxicity in the rabbit ( Oryctolagus cuniculus )
    Moumen, Yasmina
    Malki, Samira
    Bensaas, Faiza
    Belaloui, Malika
    Boudjerar, Zohra
    Ferag, Dehbia
    ACTA VETERINARIA BRNO, 2024, 93 (02) : 183 - 199
  • [27] Mercury-induced cognitive impairment in metallothionein-1/2 null mice
    Eddins, Donnie
    Petro, Ann
    Pollard, Ninitia
    Freedman, Jonathan H.
    Levin, Edward D.
    NEUROTOXICOLOGY AND TERATOLOGY, 2008, 30 (02) : 88 - 95
  • [28] Astrocytes as modulators of mercury-induced neurotoxicity
    Aschner, M
    NEUROTOXICOLOGY, 1996, 17 (3-4) : 663 - 669
  • [29] Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice
    Fagoonee, Sharmila
    Caorsi, Cristiana
    Giovarelli, Mirella
    Stoltenberg, Meredin
    Silengo, Lorenzo
    Altruda, Fiorella
    Camussi, Giovanni
    Tolosano, Emanuela
    Bussolati, Benedetta
    JOURNAL OF IMMUNOLOGY, 2008, 181 (03): : 1937 - 1947
  • [30] Zinc alleviates mercury-induced oxidative stress in Pfaffia glomerata (Spreng.) Pedersen
    Calgaroto, Niceia Spanholi
    Cargnelutti, Denise
    Rossato, Liana Veronica
    Farias, Julia Gomes
    Nunes, Sibila Trojahn
    Tabaldi, Luciane Almeri
    Antes, Fabiane Goldschmidt
    Moraes Flores, Erico Marlon
    Chitolina Schetinger, Maria Rosa
    Nicoloso, Fernando Teixeira
    BIOMETALS, 2011, 24 (05) : 959 - 971