Sample size/power calculation for stratified case-cohort design

被引：4

作者：

Hu, Wenrong ^{[1
,2
]}

Cai, Jianwen ^{[3
]}

Zeng, Donglin ^{[3
]}

机构：

[1] Univ Memphis, Dept Math Sci, Memphis, TN 38152 USA

[2] CSL Behring, Dept Biostat, King Of Prussia, PA 19406 USA

[3] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA

来源：

STATISTICS IN MEDICINE | 2014年 / 33卷 / 23期

关键词：

case-cohort design; power calculation; sample size; sampling technique; stratified case-cohort design; CORONARY-HEART-DISEASE; BREAST-CANCER; REGRESSION; RISK; WOMEN; EFFICIENCY; MODELS;

D O I：

10.1002/sim.6215

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The case-cohort (CC) study design usually has been used for risk factor assessment in epidemiologic studies or disease prevention trials for rare diseases. The sample size/power calculation for a stratified CC (SCC) design has not been addressed before. This article derives such result based on a stratified test statistic. Simulation studies show that the proposed test for the SCC design utilizing small sub-cohort sampling fractions is valid and efficient for situations where the disease rate is low. Furthermore, optimization of sampling in the SCC design is discussed and compared with proportional and balanced sampling techniques. An epidemiological study is provided to illustrate the sample size calculation under the SCC design. Copyright (C) 2014 John Wiley & Sons, Ltd.

引用

页码：3973 / 3985

页数：13

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