Ferulic acid-mediated protection against neomycin-induced hair cell loss in transgenic zebrafish

被引：9
|
作者：
Ju Chang-Chien [1 ,3 ]
Yen, Yung-Chang [4 ,5 ]
Li, Shuan-Yow [1 ]
Hsu, Tsai-Ching [3 ,6 ]
Yang, Jiann-Jou [1 ,2 ]
机构：
[1] Chung Shan Med Univ, Dept Biomed Sci, Taichung, Taiwan
[2] Chung Shan Med Univ Hosp, Dept Med Sci, Taichung, Taiwan
[3] Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, Coll Med, Taichung, Taiwan
[4] CHi Mei Med Ctr, Dept Ophthalmol, Tainan, Taiwan
[5] Min Hwei Coll Hlth Care Management, Dept Nursing, Tainan, Taiwan
[6] Chung Shan Med Univ Hosp, Clin Lab, Taichung, Taiwan
来源：
JOURNAL OF FUNCTIONAL FOODS | 2017年 / 28卷
关键词：
Transgenic zebrafish; Neomycin; ototoxicity; Ferulic acid; LATERAL-LINE; DANIO-RERIO; IN-VIVO; OTOTOXICITY; DEATH; REGENERATION; EXPRESSION; COCHLEA; DAMAGE; ANTIOXIDANTS;
D O I：
10.1016/j.jff.2016.11.019
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Ferulic acid (FA) derivatives have applied in American clinical trials for preventing and treating auditory dysfunctions. However, the effects of FA on neomycin-mediated sensorineural hearing loss are still unknown. We developed a transgenic zebrafish (pvalb3b:TagGFP) expressing green-colored hair cells in the inner ear and lateral line neuromasts by ToI2 system. Then, we determined the effects of FA on neomycin-induced ototoxicity in 4 dpf transgenic larvae. FA conferred significant protection against hair cell loss across a wide range of neomycin concentrations. In addition, FA significantly decreased intracellular ROS production and TUNAL reactions in larvae pretreated with FA prior to neomycin exposure. These findings suggest that FA has antioxidant effects and can attenuate neomycin-induced hair cell death in neuromasts. The green hair cells of transgenic zebrafish lateral line may provide a useful basis on which to investigate the cellular pathways related to the hair cell death and survival imparted by FA. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：157 / 167
页数：11
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