Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora

被引：14
|
作者：
Cheng, Lin-Yang [1 ]
Chen, Chun-Lin [2 ]
Kuo, Yueh-Hsiung [3 ,4 ]
Chang, Tsung-Hsien [5 ]
Lin, I-Wei [6 ]
Wang, Shih-Wei [6 ]
Chung, Mei-Ing [1 ]
Chen, Jih-Jung [7 ,8 ]
机构：
[1] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan
[2] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan
[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan
[4] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan
[5] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan
[6] Mackay Med Coll, Dept Med, New Taipei 252, Taiwan
[7] Natl Yang Ming Univ, Fac Pharm, Sch Pharmaceut Sci, Taipei 112, Taiwan
[8] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 10期
关键词：
Garcinia multiflora; Guttiferae; Polyprenylated polycyclic; acylphloroglucinol; Garcimultiflorone K; Angiogenesis inhibitor; DERIVATIVES; XANTHONES; FRUITS; BENZOPHENONES; SUBELLIPTICA;
D O I：
10.1016/j.bmcl.2018.04.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Gamma multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1 -3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate cancer cell line PC-3 with GI(50) values of 4.3 +/- 1.6 and 6.6 +/- 0.4 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1860 / 1863
页数：4
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