Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonala, Zapopan and rural Jalisco

被引：3

作者：

Bravo-Acevedo, Alicia ^{[1
]}

Escobedo-Ruiz, Araceli ^{[2
]}

Barquera, Rodrigo ^{[3
,4
]}

Clayton, Stephen ^{[4
]}

Eduardo Garcia-Arias, Victor ^{[5
]}

Arrieta-Bolanos, Esteban ^{[6
]}

Gone-Vazquez, Isis ^{[2
]}

Iraiz Hernandez-Zaragoza, Diana ^{[3
,7
]}

Paulina Arellano-Prado, Francia ^{[5
]}

Estefania Rodriguez-Lopez, Marla ^{[5
]}

de Jesus Sanchez-Fernandez, Maria Guadalupe ^{[8
]}

Sandoval-Sandoval, Mario J. ^{[9
]}

Gomez-Navarro, Benjamin ^{[10
]}

Zuniga, Joaquin ^{[11
,12
]}

Yunis, Edmond J. ^{[13
]}

Bekker-Mendez, Carolina ^{[14
]}

Granados, Julio ^{[15
]}

机构：

[1] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet Luis Castelazo Ayala 4, Blood Bank, Mexico City, DF, Mexico

[2] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Hosp Especialidades, Histocompatibil Lab, Guadalajara, Jalisco, Mexico

[3] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[4] Max Planck Inst Sci Human Hist MPI SHH, Dept Archaeogenet, Jena, Germany

[5] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Pediat Hosp, Guadalajara, Jalisco, Mexico

[6] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[7] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[8] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Dept Nephrol & Transplantat Unit, Guadalajara, Jalisco, Mexico

[9] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Transplantat, Guadalajara, Jalisco, Mexico

[10] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Nephrol, Guadalajara, Jalisco, Mexico

[11] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[12] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[13] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[14] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Calzada Vallejo & Jacarandas S-N, Mexico City 02990, DF, Mexico

[15] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Jalisco; Admixture; ALLELE FREQUENCIES; MESTIZOS; ADMIXTURE; DIFFERENTIATION; IMPACT;

D O I：

10.1016/j.humimm.2019.05.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2046 Mexicans from the state of Jalisco living in the city of Guadalajara (N = 1189), Tlajomulco (N = 30), Tlaquepaque (N = 39), Tonala (N = 35), Zapopan (N = 168) and rural communities (N = 585), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Jalisco include nine Native American most probable ancestry and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Jalisco are European (48.45 +/- 1.18% by ML; 41.66% of European haplotypes) and Native American (44.02 +/- 1.24% by ML; 39.86% of Native American haplotypes), while African genetic component is less apparent (7.53 +/- 0.30% by ML; 9.62% of African haplotypes).

引用

页码：502 / 505

页数：4

共 34 条

[31] Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico
Bravo-Acevedo, Alicia
Barquera, Rodrigo
Arrieta-Bolanos, Esteban
Iraiz Hernandez-Zaragoza, Diana
Clayton, Stephen
Gone-Vazquez, Isis
Escobedo-Ruiz, Araceli
Arturo Pantoja-Torres, Jorge
Adalid-Sainz, Carmen
Pacheco-Ubaldo, Hanna
Cesar Martinez-Alvarez, Julio
del Rocio Gonzalez-Martinez, Marisela
Lona-Sanchez, Abraham
Gonzalez-Medina, Liliana
Escareno-Montiel, Nestor
Araceli Arrazola-Garcia, Maria
Juarez-Barreto, Vicencio
Benitez-Arvizu, Gamaliel
Delgado-Aguirre, Hector
de Jesus Sanchez-Fernandez, Maria Guadalupe
Sandoval-Sandoval, Mario J.
Jaramillo-Rodriguez, Yolanda
Gomez-Navarro, Benjamin
Salgado-Adame, Antonio
Juarez-de la Cruz, Federico
Zuniga, Joaquin
Yunis, Edmond J.
Bekker-Mendez, Carolina
Granados, Julio
HUMAN IMMUNOLOGY, 2020, 81 (09) : 519 - 521
[32] CHARACTERIZATION OF THE HLA DIVERSITY OF MEXICAN MESTIZOS FROM MEXICO CITY, USING NEXT GENERATION SEQUENCING (NGS), AS COMPARED WITH THE GENETIC STRUCTURE OF MESTIZOS FROM OAXACA, IN SOUTHWEST MEXICO
Quezada, Betsy A.
Rodriguez, Araceli
Munguia-Saldana, Andrea
Diaz-Rivera, Adriana
Gorodezky, Clara
HUMAN IMMUNOLOGY, 2019, 80 : 95 - 95
[33] Genetic Differentiation in a Sample from Northern Mexico City Detected by HLA System Analysis: Impact in the Study of Population Immunogenetics
Juarez Cortes, Eva D.
Contreras Sieck, Miguel A.
Arriaga Perea, Agustin J.
Macias Medrano, Rosa M.
Balbuena Jaime, Anai
Everardo Martinez, Paola
Zuniga, Joaquin
Acuna Alonzo, Victor
Granados, Julio
Barquera, Rodrigo
HUMAN BIOLOGY, 2018, 89 (03) : 181 - 193
[34] Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador
Galarza, Juan M.
Barquera, Rodrigo
Tito Alvarez, Ana M.
Hernandez Zaragoza, Diana I.
Peralta Sevilla, Gabriela
Tamayo, Andrea
Perez, Mariel
Davila, David
Birnberg, Lotty
Acuna Alonzo, Victor
Krause, Johannes
Grijalva, Marcelo
HUMAN IMMUNOLOGY, 2018, 79 (09) : 639 - 650

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