Detection of Delta F508 mutation in cystic fibrosis patients from Northwestern Mexico

被引：0
|
作者：
Martinez, SEF
Arreola, MPG
Moguel, MCM
Corona, JS
机构：
来源：
ANNALES DE GENETIQUE | 1997年 / 40卷 / 03期
关键词：
cystic fibrosis; polymerase chain reaction; Delta F508 mutation; GENETIC-ANALYSIS;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In order to know the frequency of Delta F508 allele in Northwestern Mexican patients with cystic fibrosis, we carried out the amplification of a region from exon 10 of the CF gene by means of PCR in 45 unrelated patients selected by sweat test and clinical criteria, From 90 chromosomes, only 31 (34.4 %) showed the Delta F508 mutation, distributed in 9 homozygotes and 13 heterozygotes, These result suggest that other mutations are responsible of CF in the population of Northwestern Mexico.
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页码：189 / 191
页数：3
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