Synthesis of 4-amino-3-cyano-2-morpholinoquinoline

被引：0
|
作者：
Fathalla, W
Marek, J
Pazdera, P [1 ]
机构：
[1] Masaryk Univ, Dept Organ Chem, CS-61137 Brno, Czech Republic
[2] Masaryk Univ, Fac Sci, Lab Biomol Struct & Dynam, CS-61137 Brno, Czech Republic
来源：
HETEROCYCLIC COMMUNICATIONS | 2002年 / 8卷 / 01期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 4-amino-3-cyano-2-morpholinoquinoline was obtained via intramolecular Thorpe-Ziegler cyclization of 4-cyano-N-4-(2-cyanophenyl)morpholine-4-carboximido-thioate 3 to afford the intermediate 3,1-benzothiazepine A. Compound 4 undergoes ring contraction to give the quinoline 5 by base catalyzed sulfur atom elimination. IR, H-1, C-13 NMR and X-ray structural analysis confirmed the structure of the isolated new products 3 and 5.
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页码：79 / 82
页数：4
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