STRATEGIES USED TO DEVELOP ANALYTICAL METHODS FOR SIMULTANEOUS DETERMINATION OF ORGANIC COMPOUNDS BY DERIVATIVE SPECTROPHOTOMETRY

被引：6

作者：

Toral, M. Ines ^{[1
]}

Orellana y Marta Saldias, Sandra ^{[1
]}

Soto, Cesar ^{[2
]}

机构：

[1] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

[2] Univ Concepcion, Dept Quim Analit & Inorgan, Fac Ciencias Quim, Concepcion, Chile

来源：

QUIMICA NOVA | 2009年 / 32卷 / 01期

关键词：

derivative spectrophotometry; losartan; hydrochlorothiazide; LOSARTAN POTASSIUM; PHARMACEUTICAL FORMULATIONS; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; HUMAN PLASMA; HYDROCHLOROTHIAZIDE; HYPERTENSION; TABLETS; ELECTROPHORESIS; DEGRADATION;

D O I：

10.1590/S0100-40422009000100043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work is proposed, a simple experiment for the simultaneous determination of losartan (L) and hydrochlorothiazide (H) in synthetic and real samples by derivative spectrophotometry technique. For the students it is relevant to know this technique for simultaneous determinations of drugs, allowing that the students recognize that this technique is simple, rapid and applicable to quality control. This experimental work, it is proposed in order to being applied to undergraduates into laboratories of analytical chemistry. Furthermore, it is given the integration of the theoretical knowledge with the experimental work; this correlation is of interest for the students.

引用

页码：257 / U282

页数：8

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