MODELLING AND BIOPHARMACEUTICAL EVALUATION OF CICLOPIROX OLAMINE GELS

被引：0
|
作者：
Mazurkevicute, Agne [1 ]
Ramanauskiene, Kristina [1 ]
Ivaskiene, Marija [2 ]
Grigonis, Aidas [2 ]
Briedis, Vitalis [1 ]
机构：
[1] Lithuanian Univ Hlth Sci, Fac Pharm, Dept Clin Pharm, Sukileliai Ave 13, LT-50161 Kaunas, Lithuania
[2] Lithuanian Univ Hlth Sci, Fac Vet Med, Vet Acad, Dept Noninfect Dis, Tilte St 18, LT-47181 Kaunas, Lithuania
来源：
ACTA POLONIAE PHARMACEUTICA | 2017年 / 74卷 / 02期
关键词：
ciclopirox olamine; gel; rheology; chitosan; hydroxypropyl cellulose; poloxamer; 407; IN-VITRO SUSCEPTIBILITY; RHEOLOGICAL CHARACTERIZATION; HYDROXYPROPYL CELLULOSE; ANTIFUNGAL AGENTS; POLYMERS; PERMEATION; BEHAVIOR; RELEASE; SYSTEMS; SKIN;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The ciclopirox olamine (CPO) has a broad antimicrobial profile including dermatophytes, yeasts and is used in various pharmaceutical forms. The aim of this study is to evaluate the quality of the CPO gels according to biopharmaceutial tests in vino and antifungal activity assay. Hydroxypropyl cellulose, chitosan and poloxamer 407 were selected as agents gelificants. The effects of gelling agent properties and concentration on the consistency and flow characteristics have been studied by rheometer. CPO release rates from gel were measured with Franz type diffusion cells. The antifungal activity of gels was tested using agar well diffusion technique. The results of the experimental study have shown that the rheological properties of the medications depend on the selected gelling agent and the amount of it. The higher amounts of CPO were released from the poloxamer 407 gels. Though all tested CPO gels showed great inhibition of Microsponm canis.
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收藏
页码：543 / 549
页数：7
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