Chelators influenced synthesis of chitosan-carboxymethyl cellulose microparticles for controlled drug delivery

被引：28
|
作者：
Samrot, Antony V. [1 ]
Akanksha [1 ]
Jahnavi, Tatipamula [1 ]
Padmanaban, S. [1 ]
Philip, Sheryl-Ann [1 ]
Burman, Ujjala [1 ]
Rabel, Arul Maximus [1 ]
机构：
[1] Sathyabama Univ, Dept Biotechnol, Madras 600119, Tamil Nadu, India
来源：
APPLIED NANOSCIENCE | 2016年 / 6卷 / 08期
关键词：
Chitosan (CS); Carboxymethyl cellulose (CMC); Sodium tripolyphosphate (TPP); Barium chloride; ANTIMICROBIAL ACTIVITY; CANCER-THERAPY; MICROSPHERES; CURCUMIN; NANOPARTICLES; SYSTEMS; FORMULATION; VANCOMYCIN; COMPLEXES; CARRIERS;
D O I：
10.1007/s13204-016-0536-9
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this study, polyphenolic curcumin is entrapped within microcomposites made of biopolymers chitosan (CS) and carboxymethyl cellulose (CMC) formulated by ionic gelation method. Here, different concentrations of two chelating agents, barium chloride and sodium tripolyphosphate, are used to make microcomposites. Thus, the synthesized microparticles were characterized by FTIR, and their surface morphology was studied by SEM. Drug encapsulation efficiency and the drug release kinetics of CS-CMC composites are also studied. The produced microcomposites were used to study antibacterial activity in vitro.
引用
收藏
页码：1219 / 1231
页数：13
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