Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death

被引：537
|
作者：
Chinnaiyan, AM [1 ]
ORourke, K [1 ]
Lane, BR [1 ]
Dixit, VM [1 ]
机构：
[1] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109
来源：
SCIENCE | 1997年 / 275卷 / 5303期
关键词：
D O I：
10.1126/science.275.5303.1122
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-x(L) (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1 beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED3 and the ICE family of pro-apoptotic cysteine proteases.
引用
收藏
页码：1122 / 1126
页数：5
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