Antiphage activity of sera during phage therapy in relation to its outcome

被引：68
|
作者：
Lusiak-Szelachowska, Marzanna [1 ]
Zaczek, Maciej [1 ]
Weber-Dabrowska, Beata [1 ,2 ]
Miedzybrodzki, Ryszard [1 ,2 ,3 ]
Letkiewicz, Slawomir [2 ,4 ]
Fortuna, Wojciech [1 ,2 ]
Rogoz, Pawel [2 ]
Szufnarowski, Krzysztof [2 ]
Jonczyk-Matysiak, Ewa [1 ]
Olchawa, Ewa [5 ]
Walaszek, Kinga M. [6 ]
Gorski, Andrzej [1 ,2 ,3 ]
机构：
[1] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Lab Bacteriophages, Wroclaw, Poland
[2] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Phage Therapy Unit, Wroclaw, Poland
[3] Med Univ Warsaw, Inst Transplantat, Dept Clin Immunol, Warsaw, Poland
[4] Katowice Sch Econ, Inst Med Sci, Katowice, Poland
[5] IBSS BIOMED SA, Krakow, Poland
[6] Wroclaw Univ Technol, Fac Chem, Wroclaw, Poland
来源：
FUTURE MICROBIOLOGY | 2017年 / 12卷 / 02期
关键词：
antibiotic resistance; bacterial infections; bacteriophages; clinical results; human sera; phage neutralization; phage therapy; NEUTRALIZING ANTIBODY; BACTERIOPHAGE; MICE;
D O I：
10.2217/fmb-2016-0156
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: The aim was to study the association between the phage neutralization of patients' sera and the clinical outcome of phage therapy (PT). Patients: About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied.Materials & methods: Antiphage activity of sera (AAS) was examined using the phage neutralization test of different types of phages before and during PT in relation to the route of phage administration and correlated with the results of PT. Results & conclusion: The analysis of the association between AAS level and clinical results indicated that the level of AAS is not correlated with the outcome of PT.
引用
收藏
页码：109 / 117
页数：9
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