Carbapenem-resistant Pseudomonas aeruginosa: factors influencing multidrug-resistant acquisition in non-critically ill patients

被引：31
|
作者：
Pena, C. [1 ]
Suarez, C. [1 ]
Tubau, F. [2 ]
Dominguez, A. [2 ]
Sora, M. [3 ]
Pujol, M. [1 ]
Gudiol, F. [1 ]
Ariza, J. [1 ]
机构：
[1] Hosp Univ Bellvitge, IDIBELL, Infect Dis Serv, Barcelona 08907, Spain
[2] Hosp Univ Bellvitge, IDIBELL, Microbiol Serv, Barcelona 08907, Spain
[3] Hosp Univ Bellvitge, IDIBELL, Serv Pharm, Barcelona 08907, Spain
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2009年 / 28卷 / 05期
关键词：
INTENSIVE-CARE-UNIT; ACINETOBACTER-BAUMANNII; CROSS-RESISTANCE; RISK-FACTORS; INFECTIONS; EMERGENCE; BACTERIA; EXPOSURE; STRAINS;
D O I：
10.1007/s10096-008-0645-9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A cohort study was carried out on hospitalized adult non-critically ill patients (January 2003-December 2004) to identify factors associated with the acquisition of multidrug-resistant Pseudomonas aeruginosa (MDR-PA). A total of 246 non-critically patients were included, 162 (66%) who revealed MDR-PA in the first isolate and 84 (34%) who had carbapenem-resistant P. aeruginosa (CR-PA) isolates. Multivariate analysis identified nosocomial acquisition (odds ratio [OR] 2.7, 95% confidence interval [CI] 1.1-6.3), urinary catheter (OR 2.1, 95% CI 1.1-4.3), and the prior use of fluoroquinolones (OR 2.6, 95% CI 1.0-6.7) as independent risk factors associated with MDR-PA acquisition. Our results show that antibiotics, most notably, fluoroquinolones, may play a major role in the emergence of MDR-PA.
引用
收藏
页码：519 / 522
页数：4
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