Boryl Radical-Mediated C-H Activation of Inactivated Alkanes for the Synthesis of Internal Alkynes

被引：13

作者：

Han, Jia-Bin ^{[1
,2
]}

San, Htet Htet ^{[1
,2
,3
]}

Guo, Ao ^{[1
,2
]}

Wang, Long ^{[1
,2
]}

Tang, Xiang-Ying ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Hubei Key Lab Bioinorgan Chem & Mat Med, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[3] Yadanabon Univ, Dept Ind Chem, Amarapura Township 05063, Mandalay Region, Myanmar

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 09期

基金：

中国国家自然科学基金;

关键词：

pyridine-boryl radical; alkynylation; C-H functionalization; inactivated alkanes; POLARITY-REVERSAL CATALYSIS; N-HETEROCYCLIC CARBENES; ATOM ABSTRACTION; B BOND; BORANE; COORDINATION; REDUCTIONS; REACTIVITY; COMPLEXES; HALIDES;

D O I：

10.1002/adsc.202000772

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An intriguing pyridine-boryl radical-mediated C-H alkynylation reaction of inactivated alkanes was described. The reaction features mild operation condition and wide substrate scope, and affords the corresponding products in moderate to good yields. Notably, The presence of 4-cyanopyride N-oxide was key to the success of the reaction. Cyclohexane are more easily to be functionalized in this reaction than toluene, which could be rationally explained by polarity-match principle.

引用

页码：2366 / 2370

页数：5

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