CHROMATOGRAPHY METHODS IN INVESTIGATION OF LIPOPHILICITY OF THE BIOLOGICAL ACTIVE SUBSTANCES

被引：0

作者：

Odovic, Jadranka ^{[1
]}

Trbojevic-Stankovic, Jasna ^{[2
]}

机构：

[1] Fac Pharm, Inst Analyt Chem, Belgrade 11221, Serbia

[2] Clin Ctr Dr Dragisa Misovic, Belgrade 11000, Serbia

来源：

HEMIJSKA INDUSTRIJA | 2009年 / 63卷 / 01期

关键词：

Lipophilicity; Hydrophobicity; Shake flask method; High performance liquid chromatography; Thin layer chromatography; CONVERTING-ENZYME-INHIBITOR; THIN-LAYER-CHROMATOGRAPHY; STRUCTURE-(CHROMATOGRAPHIC) RETENTION RELATIONSHIPS; PERFORMANCE LIQUID-CHROMATOGRAPHY; PARTITION-COEFFICIENTS; PLANAR CHROMATOGRAPHY; SEPARATION METHODS; ACE INHIBITORS; HYDROPHOBICITY; PHASE;

D O I：

10.2298/HEMIND0901033O

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.

引用

页码：33 / 37

页数：5

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