CHROMATOGRAPHY METHODS IN INVESTIGATION OF LIPOPHILICITY OF THE BIOLOGICAL ACTIVE SUBSTANCES

被引：0
|
作者：
Odovic, Jadranka [1 ]
Trbojevic-Stankovic, Jasna [2 ]
机构：
[1] Fac Pharm, Inst Analyt Chem, Belgrade 11221, Serbia
[2] Clin Ctr Dr Dragisa Misovic, Belgrade 11000, Serbia
来源：
HEMIJSKA INDUSTRIJA | 2009年 / 63卷 / 01期
关键词：
Lipophilicity; Hydrophobicity; Shake flask method; High performance liquid chromatography; Thin layer chromatography; CONVERTING-ENZYME-INHIBITOR; THIN-LAYER-CHROMATOGRAPHY; STRUCTURE-(CHROMATOGRAPHIC) RETENTION RELATIONSHIPS; PERFORMANCE LIQUID-CHROMATOGRAPHY; PARTITION-COEFFICIENTS; PLANAR CHROMATOGRAPHY; SEPARATION METHODS; ACE INHIBITORS; HYDROPHOBICITY; PHASE;
D O I：
10.2298/HEMIND0901033O
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
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页码：33 / 37
页数：5
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