Impact of Ramadan intermittent fasting on metabolic and inflammatory profiles in type 2 diabetic patients

被引:7
|
作者
Oueslati, Ibtissem [1 ,2 ]
Kardi, Asma [1 ,2 ]
Boukhayatia, Fatma [1 ,2 ]
Hammami, Bassem [2 ,3 ]
Cheikh, Meriem [1 ]
Ben Romdhane, Neila [2 ,4 ]
Feki, Moncef [2 ,3 ]
Yazidi, Meriem [1 ,2 ]
Chihaoui, Melika [1 ,2 ]
机构
[1] La Rabta Univ Hosp, Dept Endocrinol, Tunis, Tunisia
[2] Univ Tunis El Manar, Fac Med, Rue JbelLakhdar, Tunis 1007, Tunisia
[3] La Rabta Univ Hosp, Lab Biochem, Tunis, Tunisia
[4] La Rabta Univ Hosp, Lab Hematol, Tunis, Tunisia
关键词
Type; 2; diabetes; Intermittent fasting; Anthropometric parameters; Glycemic control; Lipid profile; Inflammation; Cardiovascular risk; GLYCEMIC CONTROL; BIOCHEMICAL PARAMETERS; CARDIOVASCULAR RISK; BLOOD-PRESSURE; MELLITUS; SULFONYLUREA; HYPOGLYCEMIA; GLICLAZIDE;
D O I
10.1007/s40200-022-01046-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose The aim of this study was to assess the impact of Ramadan intermittent fasting on metabolic and inflammatory profiles in type 2 diabetic patients (T2D). Methods It was a prospective study including 55 T2D patients treated with oral hypoglycemic drugs, who intended to observe Ramadan fasting in 2019. All participants underwent a questionnaire, a physical examination, laboratory investigations, and a cardiovascular risk assessment using the Framingham score before Ramadan (T0), immediately after Ramadan (T1), and two months after Ramadan (T2). Results The mean age of participants was 54.5 +/- 10.1 years. The number of fasted days was 29.3 +/- 2.3 days. The mean total daily calorie intake decreased significantly by 19% during Ramadan (p < 10(-3)). A significant decrease in weight (79.8 +/- 12.9 vs 78.4 +/- 13.3 kg, p = 0.003), body mass index (29.8 +/- 5.4 vs 29.2 +/- 5.4 kg/m(2), p = 0.004), waist circumference (98.2 +/- 9.6 vs 96.3 +/- 10.2 cm, p = 0.015), fat body mass (24.3 +/- 9.4 vs 23.5 +/- 9.7 kg, p = 0.043) was observed at T1. The weight loss was significantly correlated with the number of fasting days (r = 0.348, p = 0.009) and was maintained at T2. Serum fructosamine increased at T1 (303.6 +/- 46 vs 333.49 +/- 59.49 mu mol/L, p < 10(-3)) and returned to its baseline levels at T2. A significant decrease in insulin (9.7 +/- 5.5 vs 7.98 +/- 5.05 mIU/L, p = 0.043), fibrinogen (3.7 +/- 0.8 vs 3.4 +/- 0.6 g/L, p = 0.003), and hs-CRP (4.8 +/- 5.7 vs 3.7 +/- 4.5 mg/L, p = 0.058) levels was observed at T1. Homocysteine level was significantly higher after Ramadan (12.2 +/- 6.2 vs 13.5 +/- 6.4 mu mol/L, p = 0.001). However, no significant changes were found in blood pressure, fasting blood glucose, HOMA-IR, uric acid, lipids, and white blood cells count. The mean Framingham score decreased insignificantly after Ramadan. Conclusions Ramadan fasting in T2D patients seems to have a favorable impact on anthropometric parameters and inflammatory profile. However, it may cause a transient worsening of glycemic control.
引用
收藏
页码:751 / 758
页数:8
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