Palladium-Catalyzed Asymmetric Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters by Allylation of β-Ketocarbonyls with Morita-Baylis-Hillman Adducts

被引：72

作者：

Liu, Jiawang ^{[1
,2
]}

Han, Zhaobin ^{[1
]}

Wang, Xiaoming ^{[1
]}

Meng, Fanye ^{[1
,2
]}

Wang, Zheng ^{[1
]}

Ding, Kuiling ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 18期

关键词：

allylic compounds; asymmetric catalysis; palladium; P ligands; spiro compounds; ENANTIOSELECTIVE ALLYLIC ALKYLATION; ALPHA-ALLYLATION; DUAL CATALYSIS; ENANTIO; LIGANDS; AMINATION; DIASTEREO; REAGENTS; HYDROGENATION; SPIROKETALS;

D O I：

10.1002/anie.201701455

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed regio-, diastereo-, and enantio-selective allylic alkylation of beta-ketocarbonyls with Morita-Baylis-Hillman adducts has been developed using a spiroketal-based diphosphine (SKP) as the ligand, thus affording a range of densely functionalized products bearing vicinal tertiary and all-carbon quaternary stereodyad in high selectivities. The utility of the protocol was demonstrated by the facile synthesis of some complex molecules by simple product transformations.

引用

页码：5050 / 5054

页数：5

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