Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

被引：73

作者：

Ma, Dik-Lung ^{[1
]}

Wu, Chun ^{[1
]}

Wu, Ke-Jia ^{[2
]}

Leung, Chung-Hang ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Fac Sci, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Macau, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 15期

基金：

中国国家自然科学基金;

关键词：

iridium(III) complex; apoptosis; mitochondria; cancer; HALF-SANDWICH IRIDIUM(III); ANTICANCER ACTIVITY; RUTHENIUM COMPLEXES; IN-VITRO; MITOCHONDRIA; SELECTIVITY; INHIBITION; THERAPY; RHODIUM; METALS;

D O I：

10.3390/molecules24152739

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

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页数：15

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