Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

被引：73

作者：

Ma, Dik-Lung ^{[1
]}

Wu, Chun ^{[1
]}

Wu, Ke-Jia ^{[2
]}

Leung, Chung-Hang ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Fac Sci, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Macau, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 15期

基金：

中国国家自然科学基金;

关键词：

iridium(III) complex; apoptosis; mitochondria; cancer; HALF-SANDWICH IRIDIUM(III); ANTICANCER ACTIVITY; RUTHENIUM COMPLEXES; IN-VITRO; MITOCHONDRIA; SELECTIVITY; INHIBITION; THERAPY; RHODIUM; METALS;

D O I：

10.3390/molecules24152739

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

引用

页数：15

共 50 条

[1] Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes
Cao J.-J.
Tan C.-P.
Chen M.-H.
Wu N.
Yao D.-Y.
Liu X.-G.
Ji L.-N.
Mao Z.-W.
Chemical Science, 2016, 8 (01) : 631 - 640
[2] Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(III) complexes
Cao, Jian-Jun
Tan, Cai-Ping
Chen, Mu-He
Wu, Na
Yao, De-Yang
Liu, Xing-Guo
Ji, Liang-Nian
Mao, Zong-Wan
CHEMICAL SCIENCE, 2017, 8 (01) : 631 - 640
[3] Mitochondria-targeting phosphorescent iridium(III) complexes for living cell imaging
Zhang, Qingqing
Cao, Rui
Fei, Hao
Zhou, Ming
DALTON TRANSACTIONS, 2014, 43 (44) : 16872 - 16879
[4] Development of Wireless Power-Transmission-Based Photodynamic Therapy for the Induction of Cell Death in Cancer Cells by Cyclometalated Iridium(III) Complexes
Yokoi, Kenta
Yasuda, Yoshitaka
Kanbe, Azusa
Imura, Takehiro
Aoki, Shin
MOLECULES, 2023, 28 (03):
[5] N-Heterocyclic Carbene-Iridium Complexes as Photosensitizers for In Vitro Photodynamic Therapy to Trigger Non-Apoptotic Cell Death in Cancer Cells
Wang, Xing
Zhang, Chen
Madji, Ryma
Voros, Camille
Mazeres, Serge
Bijani, Christian
Deraeve, Celine
Cuvillier, Olivier
Gornitzka, Heinz
Maddelein, Marie-Lise
Hemmert, Catherine
MOLECULES, 2023, 28 (02):
[6] An ER-Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non-Small-Cell Lung Cancer
Wang, Lili
Guan, Ruilin
Xie, Lina
Liao, Xinxing
Xiong, Kai
Rees, Thomas W.
Chen, Yu
Ji, Liangnian
Chao, Hui
Advanced Materials, 2020, 60 (09): : 4707 - 4715
[7] An ER-Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non-Small-Cell Lung Cancer
Wang, Lili
Guan, Ruilin
Xie, Lina
Liao, Xinxing
Xiong, Kai
Rees, Thomas W.
Chen, Yu
Ji, Liangnian
Chao, Hui
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (09) : 4657 - 4665
[8] Cyclometalated iridium(III) complexes induce immunogenic cell death in HepG2 cells via paraptosis
Liao, Jiaxin
Zhang, Yuqing
Huang, Minying
Liang, Zhijun
Gong, Yao
Liu, Ben
Li, Yuling
Chen, Jiaxi
Wu, Wei
Huang, Zunnan
Sun, Jing
BIOORGANIC CHEMISTRY, 2023, 140
[9] Ag(I) and Au(III) Mercaptobenzothiazole complexes induced apoptotic cell death
Sherine, Jositta
Upadhyay, Arun
Mishra, Amit
Kumar, Deepak
Pal, Samanwita
Harinipriya, S.
SCIENTIFIC REPORTS, 2019, 9 (1)
[10] Ag(I) and Au(III) Mercaptobenzothiazole complexes induced apoptotic cell death
Jositta Sherine
Arun Upadhyay
Amit Mishra
Deepak Kumar
Samanwita Pal
S. Harinipriya
Scientific Reports, 9

← 1 2 3 4 5 →