The dual nature of interleukin-10 in pemphigus vulgaris

被引：28
|
作者：
Cho, Michael Jeffrey [1 ]
Ellebrecht, Christoph T. [1 ]
Payne, Aimee S. [1 ]
机构：
[1] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA
来源：
CYTOKINE | 2015年 / 73卷 / 02期
关键词：
Interleukin-10; Pemphigus; Autoimmunity; SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-LYMPHOCYTE HYPERACTIVITY; T-CELLS; RHEUMATOID-ARTHRITIS; CYTOKINE PRODUCTION; DISEASE-ACTIVITY; IL-10; PRODUCTION; FUNCTIONAL-CHARACTERIZATION; RECEPTOR EXPRESSION; BLISTER FLUID;
D O I：
10.1016/j.cyto.2014.11.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. Here we review the studies on IL-10 in pemphigus vulgaris and discuss the potential pathophysiological significance of these findings in comparison to prior studies of IL-10 in other human conditions. A better understanding of the complex roles of IL-10 in immune regulation may improve our understanding of pemphigus pathogenesis and treatment. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：335 / 341
页数：7
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