Synthesis of C-14-labelled satigrel

被引：0
|
作者：
Tanaka, S [1 ]
Yamagishi, Y [1 ]
Kusano, K [1 ]
Yoshimura, T [1 ]
机构：
[1] EISAI & CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 30026,JAPAN
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1996年 / 38卷 / 05期
关键词：
anti-platelet aggregation agent; C-14-labelled satigrel; 4-cyano-5-(4'-methoxy[ring-U-C-14]phenyl)-5-(4''-methoxyphenyl)-4-pentenoic acid; synthesis;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
C-14-Labelled satigrel, or 4-cyano-5-(4'-methoxy [ring-U-C-14] phenyl)-5-(4 ''-methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4, 4'-dimethoxy [ring-U-C-14] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 mu Ci)/mg and 98.8%, respectively.
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页码：435 / 440
页数：6
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