A review of the MHC genetics of rheumatoid arthritis

被引：176
|
作者：
Newton, JL [1 ]
Harney, SMJ [1 ]
Wordsworth, BP [1 ]
Brown, MA [1 ]
机构：
[1] Univ Oxford, Botnar Res Ctr, Nuffield Orthopaed Ctr, Inst Musculoskeletal Sci, Oxford, England
来源：
GENES AND IMMUNITY | 2004年 / 5卷 / 03期
关键词：
major histocompatibility complex; rheumatoid arthritis; genetics;
D O I：
10.1038/sj.gene.6364045
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.
引用
收藏
页码：151 / 157
页数：7
相关论文
共 50 条
  • [41] The genetics revolution and the assault on rheumatoid arthritis
    Seldin, MF
    Amos, CI
    Ward, R
    Gregersen, PK
    ARTHRITIS AND RHEUMATISM, 1999, 42 (06): : 1071 - 1079
  • [42] Genetics of rheumatoid arthritis: 2018 status
    Okada, Yukinori
    Eyre, Stephen
    Suzuki, Akari
    Kochi, Yuta
    Yamamoto, Kazuhiko
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (04) : 446 - 453
  • [43] Rheumatoid arthritis genetics: 2009 update
    Plenge R.M.
    Current Rheumatology Reports, 2009, 11 (5) : 351 - 356
  • [44] Genetics of rheumatoid arthritis: confronting complexity
    Peter K Gregersen
    Arthritis Research & Therapy, 1
  • [45] Recent advances in the genetics of rheumatoid arthritis
    Raychaudhuri, Soumya
    CURRENT OPINION IN RHEUMATOLOGY, 2010, 22 (02) : 109 - 118
  • [46] Recent advances in the genetics of rheumatoid arthritis
    Deighton C.
    Criswell L.A.
    Current Rheumatology Reports, 2006, 8 (5) : 394 - 400
  • [47] Genetics of rheumatoid arthritis: GWAS and beyond
    McAllister, Kate
    Eyre, Stephen
    Orozco, Gisela
    OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS, 2011, 3 : 31 - 46
  • [48] Genetics and rheumatoid arthritis susceptibility in Iran
    Korani, Shahla
    Korani, Mitra
    Butler, Alexandra E.
    Sahebkar, Amirhossein
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (05) : 5578 - 5587
  • [49] GENETICS OF JUVENILE RHEUMATOID-ARTHRITIS
    GIORGI, PL
    RIVISTA ITALIANA DI PEDIATRIA-ITALIAN JOURNAL OF PEDIATRICS, 1981, 7 (04): : 307 - 312
  • [50] Genetics of autoimmune murine models of rheumatoid arthritis
    Glant, TT
    TISSUE ANTIGENS, 2004, 64 (04): : 348 - 348
12345