Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

被引：32
|
作者：
Hen-Shoval, D. [1 ,2 ]
Amar, S. [3 ]
Shbiro, L. [2 ]
Smoum, R. [4 ]
Haj, Christeene G. [4 ]
Mechoulam, R. [4 ]
Zalsman, G. [5 ,6 ]
Weller, A. [1 ,2 ]
Shoval, G. [5 ,6 ]
机构：
[1] Bar Ilan Univ, Psychol Dept, Ramat Gan, Israel
[2] Bar Ilan Univ, Gonda Brain Res Ctr, Ramat Gan, Israel
[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel
[4] Hebrew Univ Jerusalem, Med Fac, Inst Drug Res, IL-91120 Jerusalem, Israel
[5] Geha Mental Hlth Ctr, Petah Tiqwa, Israel
[6] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
来源：
BEHAVIOURAL BRAIN RESEARCH | 2018年 / 351卷
关键词：
Major depression disorder (MDD); Cannabidiolic acid methyl ester; Genetic animal models of depression; Wistar-Kyoto (WKY); Flinders Sensitive Line (FSL); Forced swim test (FST); RAT MODEL; CANNABINOIDS; INVOLVEMENT; RECEPTORS; ANXIETY; NAUSEA; MICE;
D O I：
10.1016/j.bbr.2018.05.027
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar Kyoto (WRY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
引用
收藏
页码：1 / 3
页数：3
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