On-line assay of S-captopril using an amperometric biosensor/sequential injection system

被引：23
|
作者：
Stefan, RI
van Staden, JF [1 ]
Aboul-Enein, HY
机构：
[1] Univ Pretoria, Dept Chem, ZA-0002 Pretoria, South Africa
[2] King Faisal Specialist Hosp & Res Ctr, Bioanalyt & Drug Dev Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi Arabia
来源：
ANALYTICA CHIMICA ACTA | 2000年 / 411卷 / 1-2期
关键词：
S-captopril; sequential injection analysis; amperometric biosensor; L-amino acid oxidase;
D O I：
10.1016/S0003-2670(00)00780-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An automated system for the enantiopurity test of S-captopril based on the concept of sequential injection analysis (SIA) with an amperometric biosensor (based on L-amino acid oxidase (L-AAOD)) as detector is described. The proposed system is fully computerised and is suitable for the on-line monitoring of S-captopril at a sampling rate of 80 samples per hour with an RSD <0.22% in the linear range between 0.05 and 1.50 mu-mol/l. The detection limit is 16 nmol/l. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：51 / 56
页数：6
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