Cell surface receptors in lysophospholipid signaling

被引：183
|
作者：
Anliker, B [1 ]
Chun, J [1 ]
机构：
[1] Scripps Res Inst, Dept Biol Mol, Helen L Dorris Inst Neurol & Psychiat Disorders, La Jolla, CA 92037 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 05期
关键词：
G protein-coupled receptor; lysophosphatidic acid; LPA; sphingosine; 1-phosphate; S1P;
D O I：
10.1016/j.semcdb.2004.05.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival. This review will focus on major components of lysophospholipid signaling: metabolism, identification and expression of LPA and S1P receptors, general signaling pathways and specific signaling mechanisms in mouse embryonic fibroblasts. Finally, in vivo effects of LP receptor gene deletion in mice will be discussed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：457 / 465
页数：9
相关论文
共 50 条
  • [31] Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology
    Hurst, Jillian H.
    Mumaw, Jennifer
    Machacek, David W.
    Sturkie, Carla
    Callihan, Phillip
    Stice, Steve L.
    Hooks, Shelley B.
    BMC NEUROSCIENCE, 2008, 9 (1)
  • [32] Altered cell surface expression and signaling of leptin receptors containing the fatty mutation
    Crouse, JA
    Elliott, GE
    Burgess, TL
    Chiu, L
    Bennett, L
    Moore, J
    Nicolson, M
    Pacifici, RE
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) : 18365 - 18373
  • [33] Cell surface receptors
    Deller, MC
    Jones, EY
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (02) : 213 - 219
  • [34] Lysophospholipid signaling in the function and pathology of the reproductive system
    Ye, Xiaoqin
    HUMAN REPRODUCTION UPDATE, 2008, 14 (05) : 519 - 536
  • [35] Lysophospholipid signaling in cancer and immunity at a glance Preface
    Lee, Hsinyu
    Graeler, Markus H.
    TRANSLATIONAL CANCER RESEARCH, 2015, 4 (05) : 451 - 452
  • [36] Ligand design to lysophospholipid receptors by validated computational models
    Tigyi, G.
    CHEMISTRY AND PHYSICS OF LIPIDS, 2006, 143 (1-2) : 51 - 51
  • [37] Cell-surface co-receptors: emerging roles in signaling and human disease
    Kirkbride, KC
    Ray, BN
    Blobe, GC
    TRENDS IN BIOCHEMICAL SCIENCES, 2005, 30 (11) : 611 - 621
  • [38] Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
    O'Hara, Samantha D.
    Garcea, Robert L.
    MBIO, 2016, 7 (06):
  • [39] A model for the biosynthesis and transport of plasma membrane-associated signaling receptors to the cell surface
    Popescu, Sorina C.
    FRONTIERS IN PLANT SCIENCE, 2012, 3
  • [40] Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor
    Lee, Michael J.
    Dohlman, Henrik G.
    CURRENT BIOLOGY, 2008, 18 (03) : 211 - 215
12345