Cell surface receptors in lysophospholipid signaling

被引：183
|
作者：
Anliker, B [1 ]
Chun, J [1 ]
机构：
[1] Scripps Res Inst, Dept Biol Mol, Helen L Dorris Inst Neurol & Psychiat Disorders, La Jolla, CA 92037 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 05期
关键词：
G protein-coupled receptor; lysophosphatidic acid; LPA; sphingosine; 1-phosphate; S1P;
D O I：
10.1016/j.semcdb.2004.05.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival. This review will focus on major components of lysophospholipid signaling: metabolism, identification and expression of LPA and S1P receptors, general signaling pathways and specific signaling mechanisms in mouse embryonic fibroblasts. Finally, in vivo effects of LP receptor gene deletion in mice will be discussed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：457 / 465
页数：9
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