In this paper, we use Mori theory to analyze the structure of Moishezon manifolds with Picard group equal to Z, with big canonical bundle, and which become projective after one blow-up. In this context, we study the Mori contraction on the projective model, and we show that in general the center of the blow-up has <<low>> codimension. In dimension 3, the canonical bundle is nef by a result of Kollar. We show that this result is no longer true in dimension 4 or larger than 4 by constructing explicitly some examples, which give also new Moishezon manifolds not satisfying the Demailly-Siu criterion. In dimension 4, we show that the center of the blow-up is a surface, and that our construction is the only possible one when the canonical bundle is not nef; in particular, the center of the blow-up must be P-2 in this last case.