Tissue factor pathway inhibitor can interact with platelets

被引：3

作者：

Nishioka, T ^{[1
]}

Yokota, M ^{[1
]}

Hino, M ^{[1
]}

Tsuda, I ^{[1
]}

Tatsumi, N ^{[1
]}

机构：

[1] Osaka City Univ, Sch Med, Dept Clin Lab & Med, Abeno Ku, Osaka 5458585, Japan

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 2002年 / 266卷 / 1-2期

关键词：

tissue factor pathway inhibitor; platelet aggregation; GPIIb/IIIa;

D O I：

10.1016/S0022-1759(02)00145-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. However, there is no report on interaction between TFPI and platelets other than that by Tsuji, who found that whole blood anticoagulated with TFPI exhibited remarkable decrease in platelet count. Our study revealed that washed platelets suspended in modified Tyrode's buffer (8 mM CaCl2) containing TFPI exhibit platelet aggregation. However, platelets aggregation was observed without TFPI, but its increase and intensity were slow and weak, compared to that in the presence of TFPI. This aggregation was inhibited by anti-CD41 (anti-GPIIb) antibody. This finding suggested that TFPI promotes platelet aggregation. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：181 / 184

页数：4

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