Population Pharmacokinetics of Abacavir in Pregnant Women

被引：10

作者：

Fauchet, Floris ^{[1
,2
]}

Treluyer, Jean-Marc ^{[1
,2
,3
,4
]}

Preta, Laure-Helene ^{[1
]}

Valade, Elodie ^{[1
,2
]}

Pannier, Emmanuelle ^{[5
]}

Urien, Saik ^{[1
,2
,4
]}

Hirt, Deborah ^{[1
,2
,3
,4
]}

机构：

[1] Univ Paris 05, EA 08, Sorbonne Paris Cite, Paris, France

[2] Hop Tarnier, AP HP, Unite Rech Clin, Paris, France

[3] Grp Hosp Paris Ctr, AP HP, Serv Pharmacol Clin, Paris, France

[4] INSERM, CIC 0901, Paris, France

[5] Grp Hospi, Paris Ctr, Serv Gynecol Obstet, Maternite Port Royal, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 10期

关键词：

HIV-INFECTED INFANTS; ZIDOVUDINE; PHARMACODYNAMICS; LAMIVUDINE; INDINAVIR; EFAVIRENZ; ADULTS; MODEL;

D O I：

10.1128/AAC.03469-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.

引用

页码：6287 / 6289

页数：3

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