Synthesis and Reactions of Novel 2,5-Disubstituted 1,3,4-Thiadiazoles

被引：26

作者：

Mahmoud, Mahmoud R. ^{[1
]}

Shiba, Sayed A. ^{[2
]}

El-Ziaty, Ahmed K. ^{[1
]}

Abu El-Azm, Fatma S. M. ^{[1
]}

Ismail, Mahmoud F. ^{[1
]}

机构：

[1] Ain Shams Univ, Dept Chem, Fac Sci, Cairo 11566, Egypt

[2] Shaqra Univ, Fac Sci & Arts, Dept Chem, Shaqra, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 08期

关键词：

ring closure reaction; S-alkylation; 2,5-Disubstituted 1,3,4-thiadiazoles; DERIVATIVES;

D O I：

10.1080/00397911.2013.846381

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The desired 1,3,4-thiadiazole compounds bearing different substituents were obtained by the cyclization of the corresponding thiosemicarbazide followed by the reaction with electrophilic reagents, such as aromatic aldehydes, isatin, phenyl isothiocyanate, and carbon disulfide. The newly synthesized 2,5-disubstituted 1,3,4-thiadiazoles were obtained in good yields and their structures were elucidated by spectral data and elemental analysis. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

引用

页码：1094 / 1102

页数：9

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