Antibacterial effects of Prosopis juliflora occurring in Iran

Many plants of genus Prosopis (Leguminosae) are known to be of medicinal value because of increasing bacterial resistance against antibiotics and reported side effects of drugs, researchers are trying to find new drugs and its natural source. In this study antibacterial activity of Prosopis juliflora was tested in -vitro against six gram positive and negative bacteria by paper disk diffusion and well methods. In this purpose the methanolic extract at different concentrations (0.05, 0.1, 0.2, 0.3, 0.4 mg ml (-1)) against Staphylococus aureus, Micrococcus loteus, Bacillus cereus, Shigella sonee, Pseudomonas aeruginosa and Escherichia coli were tested. Comparison were made with Amoxicillin and Methicin.Results showed that Pseudomonas aureginosa had the maximum resistant and Micrococcus luteus had the less resistant against this extract. Further work needs to be done in this extract including fractionation to isolate active constituents and subsequent pharmacological evaluation.