HuR and post-transcriptional regulation in vascular aging

被引：3
|
作者：
Wang WenGong [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100191, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2014年 / 57卷 / 08期
基金：
中国国家自然科学基金;
关键词：
HuR; mRNA turnover; translation; cell senescence; vascular aging; BINDING PROTEIN HUR; P16(INK4) MESSENGER-RNA; REPLICATIVE SENESCENCE; ENDOTHELIAL-CELLS; 3'-UNTRANSLATED REGION; EXPRESSION; GROWTH; PATHWAYS; SIRT1; PHOSPHORYLATION;
D O I：
10.1007/s11427-014-4706-2
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
HuR (ELAV11 (embryonic lethal, abnormal vision)-like 1), a ubiquitously expressed member of the ELAV-like RNA-binding protein family, has been shown to regulate the stability and translation of mRNAs that encode factors regulating cellular senescence, thereby impacting on aging. In this review, we discuss the current knowledge of HuR's role in vascular cell senescence and vascular aging.
引用
收藏
页码：863 / 866
页数：4
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