Progressive Age-Related Cognitive Decline in Tau Mice

被引：35
|
作者：
Van der Jeugd, Ann [1 ]
Vermaercke, Ben [1 ]
Derisbourg, Maxime [2 ,3 ]
Lo, Adrian C. [1 ]
Hamdane, Malika [2 ,3 ]
Blum, David [2 ,3 ,4 ]
Buee, Luc [2 ,3 ,4 ]
D'Hooge, Rudi [1 ]
机构：
[1] Univ Leuven, Fac Psychol & Educ Sci, Lab Biol Psychol, Louvain, Belgium
[2] Univ Lille Nord France, UDSL, Lille, France
[3] INSERM, Jean Pierre Aubert Res Ctr, IMPRT, U837, F-59045 Lille, France
[4] CHRU Lille, CMRR, F-59037 Lille, France
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 37卷 / 04期
关键词：
aging; learning; memory; tauopathy; transgenic model; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; LONG-TERM POTENTIATION; MORRIS WATER MAZE; ALZHEIMERS-DISEASE; SYNAPTIC-TRANSMISSION; MEMORY DEFICITS; DEPENDENT IMPAIRMENT; ODOR DISCRIMINATION; HIPPOCAMPAL-NEURONS;
D O I：
10.3233/JAD-130110
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Age-related cognitive decline and neurodegenerative diseases are a growing challenge for society. Accumulation of tau pathology has been proposed to partially contribute to these impairments. This study provides a behavioral characterization during aging of transgenic mice bearing tau mutations. THY-Tau22 mice were evaluated at ages wherein tau neuropathology in this transgenic mouse model is low (3-4 months), moderate (6-7 months), or extensive (>9 months). Spatial memory was found to be impaired only after 9 months of age in THY-Tau22 mice, whereas non-spatial memory was affected as early as 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing tauopathies through modulation of tau kinetics.
引用
收藏
页码：777 / 788
页数：12
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