An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin

被引：33
|
作者：
King, Ryan W. [1 ]
Bauer, John D. [1 ]
Brady, Sean F. [1 ]
机构：
[1] Rockefeller Univ, Lab Genetically Encoded Small Mol, New York, NY 10065 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 34期
关键词：
biosynthesis; DNA; metagenomics; natural products; polyketides; GENE CLUSTERS; NATURAL-PRODUCTS; SYNTHASE GENES; STREPTOMYCES-COELICOLOR; HETEROLOGOUS EXPRESSION; PROKARYOTIC DIVERSITY; SOIL; LIBRARIES; MICROORGANISMS; BACTERIA;
D O I：
10.1002/anie.200901209
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A down to earth approach: Environmental (from desert soil) DNA derived cosmid clones containing type II polyketide synthase genes were screened for their ability to produce clone-specific metabolites in Streptomyces. One of the Streptomyces recombinants produces erdacin (1), a polyketide with a previously unknown pentacyclic structure. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6257 / 6261
页数：5
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