Highly enantioselective hydrogenation of α-Alkyl-β-arylpropenoic acids over cinchonidine-modified palladium catalyst

被引：22

作者：

Sugimura, Takashi ^{[1
]}

Watanabe, Junya ^{[1
]}

Uchida, Takayuki ^{[1
]}

Nitta, Yuriko ^{[1
]}

Okuyama, Tadashi ^{[1
]}

机构：

[1] Osaka Univ, Osaka 540, Japan

来源：

CATALYSIS LETTERS | 2006年 / 112卷 / 1-2期

关键词：

asymmetric synthesis; enantioselective hydrogenation; palladium on carbon; olefin;

D O I：

10.1007/s10562-006-0159-y

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Enantioselective hydrogenation of (E)- alpha-alkyl-beta-arylpropenoic acids was studied over the cinchonidine-modified Pd/C under the conditions optimized for (E)-alpha,beta-diarylpropenoic acids. Enantiomeric excess (ee) of the product was increased by adjusting the alpha-alkyl group as a properly bulky isopropyl. The ee was as high as 80% when the beta-group is phenyl, and reached 86% with p-anisyl group. Stereoselection of those substrates is similar to that of (E)-alpha,beta-diarylpropenoic acids.

引用

页码：27 / 30

页数：4

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