Clinical use of micafungin for the treatment of invasive candidiasis in critical ill patients

Background: Over the last 30 years a significant increase of Candida spp. invasive disease has been observed in non-neutropenic critical ill patients. Both fluconazole and amphotericin B have been considered first line treatment for invasive (proven and probable) Candida spp. disease, although the mortality rate is still high. Objectives: To review the current data on the use of micalungin for the treatment of Candida invasive disease in critical ill patients. Methods: The pharmacologic, mycological and clinical properties of micafungin are reviewed based on Current published data. The use and efficacy of micafungin for the treatment of Candida invasive disease in critical ill patients is discussed. Results and conclusions: To reduce the rate of mortality more effective antifungals and pre-emptive treatment strategies are Currently warranted. Candins achieve better results for the treatment of invasive Candida disease in non-neutropenic critical ill patients. Micafungin has a good safety profile (similar to fluconazole), Micafungin is a first line drug for the treatment of invisive Candida disease and may be used as a pre- emptive approach followed by a de-escalating strategy with azoles. (C) 2009 Revista Iberoamericana de Micologia. Published by Elsevier Espana, S.L. All rights reserved.