Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO)

被引：65

作者：

Penack, Olaf ^{[1
]}

Becker, Carolin ^{[2
]}

Buchheidt, Dieter ^{[3
]}

Christopeit, Maximilian ^{[4
]}

Kiehl, Michael ^{[5
]}

von Lilienfeld-Toal, Marie ^{[6
]}

Hentrich, Marcus ^{[7
]}

Reinwald, Marc ^{[3
]}

Salwender, Hans ^{[8
]}

Schalk, Enrico ^{[9
]}

Schmidt-Hieber, Martin ^{[10
]}

Weber, Thomas ^{[4
]}

Ostermann, Helmut ^{[11
]}

机构：

[1] Charite Campus Virchow Klinikum, Dept Hematol Oncol & Tumourimmunol, D-13353 Berlin, Germany

[2] Rhein Westfal TH Aachen, Fac Med, Dept Oncol Hematol & Stem Cell Transplantat, Aachen, Germany

[3] Heidelberg Univ, Dept Internal Med, Univ Med Ctr Mannheim, Heidelberg, Germany

[4] Univ Hosp Martin Luther Univ, Halle, Saale, Germany

[5] Klinikum Frankfurt Oder, Dept Hematol & Oncol, Frankfurt, Germany

[6] Univ Jena, Dept Hematol & Oncol, Jena, Germany

[7] Harlaching Hosp, Dept Hematol Oncol & Palliat Care, Munich, Germany

[8] Asklepios Hosp Altona, Dept Hematol & Oncol, Hamburg, Germany

[9] Univ Magdeburg, Med Ctr, Dept Hematol & Oncol, D-39106 Magdeburg, Germany

[10] HELIOS Clin Berlin Buch, Clin Hematol Oncol & Tumourimmunol, Berlin, Germany

[11] Univ Munich, Dept Internal Med 3, Munich, Germany

来源：

ANNALS OF HEMATOLOGY | 2014年 / 93卷 / 07期

关键词：

Guideline; Sepsis; Neutropenia; Management; CRITICALLY-ILL PATIENTS; RENAL-REPLACEMENT THERAPY; INTENSIVE INSULIN THERAPY; BLOOD-STREAM INFECTIONS; ACUTE RESPIRATORY-FAILURE; HIGH-DOSE ANTITHROMBIN; EXTRACORPOREAL MEMBRANE-OXYGENATION; AMINOGLYCOSIDE COMBINATION THERAPY; INTERLEUKIN-1 RECEPTOR ANTAGONIST; HUMAN SOLUBLE THROMBOMODULIN;

D O I：

10.1007/s00277-014-2086-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sepsis is a major cause of mortality during the neutropenic phase after intensive cytotoxic therapies for malignancies. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. Clinical guidelines on sepsis treatment have been published by others. However, optimal management may differ between neutropenic and non-neutropenic patients. Our aim is to give evidence-based recommendations for haematologist, oncologists and intensive care physicians on how to manage adult patients with neutropenia and sepsis.

引用

页码：1083 / 1095

页数：13

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